ATF6

Activating transcription factor 6
Identifiers
Symbols ATF6;
External IDs OMIM: 605537 MGI: 1926157 HomoloGene: 32015 GeneCards: ATF6 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 22926 226641
Ensembl ENSG00000118217 ENSMUSG00000026663
UniProt P18850 n/a
RefSeq (mRNA) NM_007348 NM_001081304.1
RefSeq (protein) NP_031374 NP_001074773.1
Location (UCSC) Chr 1:
161.74 – 161.93 Mb		 Chr 1:
172.63 – 172.8 Mb
PubMed search [1] [2]

Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene[1][2][3] and is involved in unfolded protein response.

Contents

Function

ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[4] Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.

See also

Interactions

ATF6 has been shown to interact with YY1[5] and Serum response factor.[2]

References

  1. ^ Hai TW, Liu F, Coukos WJ, Green MR (December 1989). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers". Genes Dev. 3 (12B): 2083–90. doi:10.1101/gad.3.12b.2083. PMID 2516827. 
  2. ^ a b Zhu C, Johansen FE, Prywes R (September 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. 17 (9): 4957–66. PMC 232347. PMID 9271374. http://mcb.asm.org/cgi/content/abstract/17/9/4957. 
  3. ^ Meex SJ, van Greevenbroek MM, Ayoubi TA, Vlietinck R, van Vliet-Ostaptchouk JV, Hofker MH, Vermeulen VM, Schalkwijk CG, Feskens EJ, Boer JM, Stehouwer CD, van der Kallen CJ, de Bruin TW (July 2007). "Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians". J. Clin. Endocrinol. Metab. 92 (7): 2720–5. doi:10.1210/jc.2006-2280. PMID 17440018. 
  4. ^ "Entrez Gene: ATF6 activating transcription factor 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22926. 
  5. ^ Li, M; Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee A S (July 2000). "ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1". Mol. Cell. Biol. (UNITED STATES) 20 (14): 5096–106. doi:10.1128/MCB.20.14.5096-5106.2000. ISSN 0270-7306. PMC 85959. PMID 10866666. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85959. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.